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KMID : 0882420120820060724
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Korean Journal of Medicine
2012 Volume.82 No. 6 p.724 ~ p.728
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A Case of Kounis Syndrome Induced by a Non-Steroidal Anti-Inflammatory Drug
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Choi Eun-Jeong
Shin Yun-ho
Na Dong-Kil
Kim Ji-Hyun
Choi Seong-Hoon
Cho Jung-Rae
Lee Nam-ho
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Abstract
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In 1991, Kounis and Zavras described the ‘‘syndrome of allergic angina’’ as the coincidental occurrence of angina and allergic reactions by inflammatory mediators released during the allergic insult. Presently, both allergic angina and allergic myocardial infarction are referred to as ‘‘Kounis syndrome.” Several allergens, including drugs, Hymenoptera venom, latex, food, and contrast media have been reported to trigger Kounis syndrome. Three variants of this syndrome have been described. Type I includes patients with normal coronary arteries, Type II includes patients with preexisting atheromatous disease where acute release of inflammatory mediators can induce coronary artery spasms, and Type III is associated with intracoronary thrombus formation caused by an allergic reaction. We report a case of Kounis syndrome who presented as acute myocardial infarction after intramuscular injection of a non-steroidal anti-inflammatory drug.
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KEYWORD
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Anaphylaxis, Myocardial infarction, Syndrome
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